{"id":67670,"date":"2026-09-21T00:28:07","date_gmt":"2026-09-21T00:28:07","guid":{"rendered":"http:\/\/zydq.1006ss.com\/?p=67670"},"modified":"2026-09-21T00:28:07","modified_gmt":"2026-09-21T00:28:07","slug":"%e8%b0%81%e8%83%bd%e6%83%b3%e5%88%b0%ef%bc%8c%e5%a5%bd%e5%a5%bd%e5%88%b7%e7%89%99%e5%b1%85%e7%84%b6%e8%83%bd%e9%a2%84%e9%98%b2%e8%80%81%e5%b9%b4%e7%97%b4%e5%91%86%ef%bc%9f%ef%bc%81","status":"publish","type":"post","link":"http:\/\/zydq.ybx8.cn\/?p=67670","title":{"rendered":"\u8c01\u80fd\u60f3\u5230\uff0c\u597d\u597d\u5237\u7259\u5c45\u7136\u80fd\u9884\u9632\u8001\u5e74\u75f4\u5446\uff1f\uff01"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u8bba\u6587\uff1a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5927\u8111\u4e2d\u7684\u7259\u9f88\u9f88\u6c9f\u5355\u80de\u83cc\uff1a\u75be\u75c5\u56e0\u679c\u5173\u7cfb\u7684\u8bc1\u636e\u53ca\u5c0f\u5206\u5b50\u6291\u5236\u5242\u7684\u6cbb\u7597\u4f5c\u7528<br \/>Porphyromonas gingivalis in Alzheimer\u2019s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors<\/p>\n<p class=\"wp-block-paragraph\">&#x1f9e0; \u6700\u65b0\u7814\u7a76\u8868\u660e\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u53ef\u80fd\u4e0e\u7259\u9f88\u7ec6\u83cc\u6709\u5173\u3002\u6ca1\u9519\uff0c\u8fd9\u79cd\u75be\u75c5\u53ef\u80fd\u5e76\u975e\u6e90\u4e8e\u5927\u8111\uff0c\u800c\u662f\u53e3\u8154\u611f\u67d3\u3002\u65b0\u5174\u7814\u7a76\u63ed\u793a\u4e86\u7259\u9f88\u75be\u75c5\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e4b\u95f4\u4ee4\u4eba\u60ca\u8bb6\u7684\u8054\u7cfb\uff0c\u8fd9\u4e3a\u7406\u89e3\u4e43\u81f3\u9884\u9632\u8fd9\u79cd\u6700\u5177\u7834\u574f\u6027\u7684\u8111\u90e8\u75be\u75c5\u4e4b\u4e00\u5e26\u6765\u4e86\u6f5c\u5728\u7684\u7a81\u7834\u3002\u79d1\u5b66\u5bb6\u5728\u5df2\u6545\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u5927\u8111\u4e2d\u53d1\u73b0\u4e86\u7259\u9f88\u535f\u5549\u5355\u80de\u83cc\uff08Porphyromonas gingivalis\uff09\uff0c\u8fd9\u79cd\u7ec6\u83cc\u6b63\u662f\u5bfc\u81f4\u6162\u6027\u7259\u9f88\u75be\u75c5\u7684\u7f6a\u9b41\u7978\u9996\u3002\u5728\u5b9e\u9a8c\u5ba4\u5b9e\u9a8c\u4e2d\uff0c\u611f\u67d3\u4e86\u8fd9\u79cd\u7ec6\u83cc\u7684\u5c0f\u9f20\u51fa\u73b0\u4e86\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u5178\u578b\u7279\u5f81\uff0c\u5305\u62ec\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u2014\u2014\u4e00\u79cd\u957f\u671f\u4ee5\u6765\u4e0e\u8be5\u75be\u75c5\u76f8\u5173\u7684\u86cb\u767d\u8d28\u3002\u66f4\u5f15\u4eba\u6ce8\u76ee\u7684\u662f\uff0c\u5728\u51fa\u73b0\u4efb\u4f55\u75c7\u72b6\u4e4b\u524d\uff0c\u4e00\u4e9b\u5927\u8111\u5c31\u5df2\u53d1\u751f\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u76f8\u5173\u7684\u65e9\u671f\u53d8\u5316\u7684\u4eba\u7fa4\u4e2d\uff0c\u5c31\u53d1\u73b0\u4e86\u6709\u6bd2\u7684\u7ec6\u83cc\u9176\u2014\u2014\u8fd9\u8868\u660e\u8fd9\u79cd\u611f\u67d3\u53ef\u80fd\u5728\u6570\u5e74\u524d\u5c31\u5f15\u53d1\u4e86\u635f\u5bb3\u3002\u8fd9\u4e00\u53d1\u73b0\u4e3a\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u5e26\u6765\u4e86\u5e0c\u671b\u3002\u4e00\u79cd\u540d\u4e3a COR388\uff08\u7531 Cortexyme \u516c\u53f8\u7814\u53d1\uff09\u7684\u5b9e\u9a8c\u6027\u836f\u7269\u5df2\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u51cf\u5c11\u7ec6\u83cc\u548c\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u79ef\u7d2f\u7684\u6f5c\u529b\u3002\u867d\u7136\u8fd8\u9700\u8981\u66f4\u591a\u7814\u7a76\u548c\u4eba\u4f53\u8bd5\u9a8c\uff0c\u4f46\u8fd9\u4e9b\u53d1\u73b0\u652f\u6301\u4e86\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u53ef\u80fd\u5177\u6709\u611f\u67d3\u56e0\u7d20\u800c\u975e\u4ec5\u4ec5\u662f\u9000\u884c\u6027\u56e0\u7d20\u7684\u89c2\u70b9\u3002\u76ee\u524d\uff0c\u7814\u7a76\u4eba\u5458\u6301\u8c28\u614e\u4e50\u89c2\u7684\u6001\u5ea6\u2014\u2014\u4f46\u5176\u610f\u4e49\u91cd\u5927\uff1a\u4fdd\u6301\u826f\u597d\u7684\u53e3\u8154\u536b\u751f\u4e0d\u4ec5\u80fd\u8ba9\u4f60\u62e5\u6709\u707f\u70c2\u7684\u7b11\u5bb9\uff0c\u8fd8\u6709\u52a9\u4e8e\u4fdd\u62a4\u4f60\u7684\u5927\u8111\u3002<\/p>\n<p class=\"wp-block-paragraph\">\u6765\u6e90\uff1aDominy, SS \u7b49 (2019)\u3002\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8111\u4e2d\u7684\u7259\u9f88\u535f\u5549\u5355\u80de\u83cc\uff1a\u75be\u75c5\u81f4\u75c5\u6027\u548c\u5c0f\u5206\u5b50\u6291\u5236\u5242\u6cbb\u7597\u7684\u8bc1\u636e\u3002\u300a\u79d1\u5b66\u8fdb\u5c55\u300b\u3002<\/p>\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" title=\"\u8c01\u80fd\u60f3\u5230\uff0c\u597d\u597d\u5237\u7259\u5c45\u7136\u80fd\u9884\u9632\u8001\u5e74\u75f4\u5446\uff1f\uff01 - 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